Cheng Mao-huang graduated from the Taiwan Provincial Hsinchu Provincial Normal College. He was very interested in painting while he was student. He won a prize in the Taiwan Teacher Art Show in 1968, which encouraged him to create more paintings. In 1970s, Cheng received several awards including the Golden Prizes of the 38th and 40th Taiyang Fine Arts Exhibition. Taiwan Museum of Art held his solo exhibition in 1981.